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In a large bowl, use your hands to mix together the ground beef, panko bread crumbs, 2 tablespoons worcestershire sauce, the dijon mustard, ½ cup of the barbecue sauce, 1 tablespoon honey, salt, and black pepper.
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Shape the mixture into a long, thick log and place in an oiled baking dish. Be careful not to pack the meat too tightly or you’ll end up with a very dense, tough loaf.
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In a small bowl, whisk together the remaining ¼ cup barbecue sauce, 1 tablespoon honey, and 2 teaspoons worcestershire sauce. Spread half of this mixture evenly all over the meatloaf. Reserve the other half for serving.
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Bake for 45 minutes to an hour. Slice and drizzle with reserved honey barbecue sauce.