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Preheat oven to 350F. Butter a 9x5" loaf pan.
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Sift together flour, baking powder, baking soda, and salt. Set aside.
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Cream butter and sugar together until light and fluffy. Add eggs, one at at time, and beat until combined. Add zest, juice, sour cream, and vanilla and beat until everything is incorporated. Slowly add in flour and beat until just combined. Pour into the prepared loaf pan.
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Bake for 45 - 50 minutes, until a toothpick inserted into the center comes out clean. Cool in pan for about 10 minutes and then remove to a wire rack with aluminum foil or paper towels underneath. Use a fork to poke holes in the loaf.