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In a large microwavable bowl, mix cereal, popcorn, peanuts and pumpkin seeds; set aside.
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In a small saucepan, heat butter, brown sugar, and corn syrup on high over medium-low heat until mixture is boiling, stirring occasionally; stir in vanilla pumpkin pie spice. Pour over cereal mixture, stirring until evenly coated.
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Microwave 5 to 6 minutes, stirring and scraping bowl after every minute. Spread on waxed paper to cool, about 15 minutes, stirring occasionally to break up.
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Stir in harvest mix. Store in airtight container.